Pitchiaya Lab

¹ First author, * Equal Contribution, ^C Corresponding author

Select Publications

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All Publications

Google Scholar: https://scholar.google.com/citations?user=flPaAgUAAAAJ&hl=en&oi=ao

1. Cho H^1*, Zhang Y^1*, Tien JC, Mannan R, Luo J, Narayanan SP, Mahapatra S, Hu J, Shelley G, Cruz G, Shahine M, Wang L, Su S, Wang R, Cao X, Dhanasekaran SM, Keller ET, Pitchiaya S^1*,C, Chinnaiyan AM^C, Cellular cartography reveals mouse prostate organization and determinants of castration resistance, PNAS (2025)
2. Patel P^1*, Nallandhighal S^1*, Scoville D, Cotta B, Knuth Z, Triner D, Tran L, Udager AM, Rao A, Morgan TM, Palapattu GS, Dadhania V, Pitchiaya S, Salami SS^C, Spatial Transcriptomic Profiling to Characterize the Nature of Peripheral- Versus Transition-zone Prostate Cancer, European Urology Focus (2024)
3. Gao G¹, Sumrall E, Pitchiaya S, Bitzer M, Alberti S and Walter N^C, Biomolecular Condensates in Kidney Physiology and Disease, Nature Reviews Nephrology (2023)
4. Duran E¹, Schmidt A, Welty R, Jalihal AP, Pitchiaya S and Walter NG^C, Utilizing functional cell-free extracts to dissect ribonucleoprotein complex biology at single-molecule resolution, WIREs RNA (2023)
5. Larouche J^1*, Mohiuddin M^1*, Choi JJ^1*, Ulintz PJ, Fraczek PM, Sabin K, Pitchiaya S, Kurpiers SJ, Castor-Macias J, Liu W, Hastings RL, Brown LA, Markworth JF, De Silva K, Levi BD, Merajver SD, Valdez G, Chakkalakal JV, Jang Y^C, Brooks S^C and Aguilar CA^C, Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging, Elife (2021)
6. Zhang Y^1*, Narayanan SP^1*, Mannan R, Raskind G, Wang X, Vats P, Su F, Hosseini N, Cao X, Kumar-Sinha C, Ellison SJ, Giordono TJ, Morgan TM, Pitchiaya S, Alva A, Mehra R, Cieslik M, Dhanasekaran SM, Chinnaiyan AM^C, Single Cell Analyses of Renal Cell Cancers Reveal Insights into Tumor Microenvironment, Cell of Origin, and Therapy Response, PNAS (2021)
7. Peltier D¹, Radosevich M, Decoville T, Pitchiaya S, Wood SC, Hou G, Zajac C, Oravecz-Wilson K, Sokol D, Henig I, Wu J, Kim S, Taylor A, Fujiwara H, Sun Y, Chinnaiyan AM, Goldstein DR and Reddy P^C, RNA-seq of Human T-Cells After Hematopoietic Stem Cell Transplantation Identifies Linc00402 as a Novel Regulator of T-Cell Alloimmunity. Science Translational Medicine (2021)
8. Zaslavsky A^1,C, Adams M, Cao X, Hawley M, Henderson J Busch-Ostergren P, Udager A, Pitchiaya S, Tourdot B, Kasputis T, Church SJ, Lee SK, Ohl S, Patel S, Morgan TM, Alva A, Wakefield TW, Reichert Z, Holinstat M and Palapattu GS^C. Antisense oligonucleotides and nucleic acids generate hypersensitive platelets. Thrombosis research (2021)
9. Jalihal AP¹, Schmidt A, Gao G, Little SR, Pitchiaya S and Nils G. Walter^C, Hyperosmotic phase separation: Condensates beyond inclusions, granules and organelles, Journal of Biological Chemistry (2021) 296:100044
10. Qiao Y^1*, Wang X^1*, Mannan R^1*, Pitchiaya S, Zhang Y, Wotring JW, Xiao L, Robinson DR, Wu Y, Tien JC, Cao X, Simko SA, Apel IJ, Kregel S, Narayanan SP, Raskind G, Ellison SJ, Parolia A, Zelenka-Wang S, McMurry L, Su F, Wang R, Cheng Y, Delekta AD, Mei Z, Pretto CD, Wang S, Mehra R^C, Sexton JZ^C and Chinnaiyan AM^C, Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2, PNAS (2021)
11. Jalihal AP^1*, Pitchiaya S^1,C*, Xiao L, Bawa P, Jiang X, Bedi K, Cieslik M, Ljungman M, Chinnaiyan AM^C and Walter NG^C, Multivalent proteins rapidly and reversibly phase-separate upon osmotic cell volume change. Molecular Cell (2020). Featured in Majumder et al., Molecular Cell, 2020 (Preview)
12. Shankar S^1*, Tien JC^1*, Siebenaler RF^1*, Chugh S^1*, Dommeti VL, Zelenka-Wang S, Wang XM, Apel IJ, Waninger J, Eyunni S, Xu A, Mody M, Goodrum A, Zhang Y, Tesmer JJ, Mannan R, Cao X, Vats P, Pitchiaya S, Shi J, Kumar-Sinha C, Crawford H and Chinnaiyan AM^C. An Essential Role for Argonaute 2 in EGFR-KRAS Signaling in Pancreatic Cancer Development. Nature Communications (2020)
13. Pitchiaya S^1,C, Mourao MDA, Jalihal AP, Xiao L, Jiang X, Chinnaiyan AM, Schnell S and Walter NG^C, Dynamic recruitment of single RNAs to processing bodies depends on RNA functionality. Molecular Cell (2019). Featured in Chowdhury et al., Molecular Cell, 2019 (Preview)
14. Parolia A^1*, Cieslik M^1*, Chu SC, Xiao L, Ouchi T, Zhang Y, Wang X, Vats P, Cao X, Pitchiaya S, Su F, Wang R, Feng FY, Wu YM, Lonigro RJ, Robinson DR and Chinnaiyan AM^C. Distinct structural classes of activating FOXA1 alterations in advanced prostate cancer. Nature (2019). Featured in Stone L, Nature Reviews Urology, 2019 (In Brief)
15. Zhang Y^1*, Pitchiaya S^1*, Cieslik M^1*, Niknafs YS, Tien JC, Hosono Y, Iyer MK, Yazdani S, Subramaniam S, Shukla SK, Jiang X, Wang L, Liu TY, Uhl M, Gawronski AR, Qiao Y, Xiao L, Dhanasekaran SM, Juckette KM, Kunju LP, Cao X, Patel U, Batish M, Shukla GC, Paulsen MT, Ljungman M, Jiang H, Mehra R, Backofen R, Sahinalp CS, Freier SM, Watt AT, Guo S, Wei JT, Feng FY, Malik R and Chinnaiyan AM^C, Analysis of the androgen receptor–regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression, Nature Genetics (2018)
16. Hosono Y^1*, Niknafs YS^1*, Prensner JR, Iyer MK, Dhanasekaran SM, Mehra R, Pitchiaya S, Tien J, Escara-Wilke J, Poliakov A, Chu SC, Saleh S, Sankar K, Su F, Guo S, Qiao Y, Freier SM, Bui HH, Cao X, Malik R, Johnson TM, Beer DG, Feng FY, Zhou W and Chinnaiyan AM^C, Oncogenic Role of THOR, a Conserved Cancer/Testis Long Noncoding RNA. Cell (2017)
17. Michelini F¹, Pitchiaya S, Vitelli V, Sharma S, Gioia U, Pessina F, Cabrini M, Wang Y, Capozzo I, Iannelli F, Matti V, Francia S, Shivashankar GV, Walter NG and d’Adda di Fagagna F^C, Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks. Nature Cell Biology (2017). Featured in Storici et al., Nature Cell Biology, 2017 (News & Views) 
18. Pitchiaya S¹, Heinicke LA, Park JI, Cameron E and Walter NG^C, Resolving sub-cellular miRNA trafficking and turnover at single-molecule resolution. Cell Reports (2017)
19. Wang X¹, Qiao Y, Asangani IA, Ateeq B, Poliakov A, Cieślik M, Pitchiaya S, Chakravarthi BVSK, Cao X, Jing X, Wang CX, Apel IJ, Wang R, Tien JC, Juckette KM, Yan W, Jiang H, Wang S, Varambally S and Chinnaiyan AM^C, Development of peptidomimetic inhibitors of the ERG gene fusion product in prostate cancer. Cancer Cell (2017)
20. Rossiello F¹, Aguado J, Sepe S, Iannelli F, Nguyen Q, Pitchiaya S, Carninci P and d’Adda di Fagagna F^C, DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs. Nature Communications (2017)
21. Niknafs YS^1*, Han S^1*, Ma T, Speers C, Zhang C, Wilder-Romans K, Iyer MK, Pitchiaya S, Malik R, Hosono Y, Prensner JR, Poliakov A, Singhal U, Xiao L, Kregel S, Siebenaler RF, Zhao SG, Uhl M, Gawronski A, Hayes DF, Pierce LJ, Cao X, Collins C, Backofen R, Sahinalp CS, Rae JM, Chinnaiyan AM^C and Feng FY^C, The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression. Nature Communications (2016)
22. Shankar S¹, Pitchiaya S, Malik R, Kothari V, Hosono Y, Yocum AK, Gundlapalli H, White Y, Firestone A, Cao X, Dhanasekaran SM, Stuckey JA, Bollag G, Shannon K, Walter NG, Kumar-Sinha C and Chinnaiyan AM^C, KRAS engages AGO2 to enhance cellular transformation. Cell Reports (2016). Featured in Kiberstis PA, Science, 2016 (Editor’s choice)
23. Nyati S¹, Schinske-Sebolt K, Pitchiaya S, Chekhovskiy K, Chator A, Chaudhry N, Dosch J, Van Dort ME, Varambally S, Kumar-Sinha C, Nyati MK, Ray D, Walter NG, Yu H, Ross BD and Rehemtulla A^C, The kinase activity of the Ser/Thr kinase BUB1 promotes TGF-β signaling. Science Signaling (2015). Featured in Moustakas et al., Science Signaling, 2015 (Focus) and Barcellos-Hoff MH, Neoplasia, 2015 (Commentary)
24. Bartke RM, Cameron EL, Cristie-David AS, Custer TC, Denies MS, Daher M, Dhakal S, Ghosh S, Heinicke LA, Hoff JD, Hou Q, Kahlscheuer ML, Karslake J, Krieger AG, Li J, Li X, Lund PE, Vo NN, Park J, Pitchiaya S, Rai V, Smith DJ, Suddala KC, Wang J, Widom JR and Walter NG^C, Meeting report: SMART timing-principles of single molecule techniques course at the University of Michigan 2014. Biopolymers (2015)
25. Pitchiaya S¹, Heinicke LA¹, Custer TC¹ and Walter NG^C, Single molecule fluorescence approaches shed light on intracellular RNAs. Chemical Reviews (2014). Featured in F1000 prime
26. Pitchiaya S¹, Krishnan V, Custer TC and Walter NG^C, Dissecting non-coding RNA mechanisms in cellulo by single molecule high resolution localization and counting. Methods (2013)
27. Ma J¹, Liu Z, Michelotti N, Pitchiaya S, Veerapaneni RS, Androsavich JR, Walter NG and Yang W^C, High-resolution three-dimensional mapping of mRNA export through the nuclear pore. Nature Communications (2013)
28. Pitchiaya S¹, Androsavich JR and Walter NG^C, Intracellular single molecule microscopy reveals two kinetically distinct pathways for microRNA assembly. EMBO reports (2012)
29. Kuszak AJ¹, Pitchiaya S, Anand JP, Mosberg HI, Walter NG and Sunahara RK^C, Purification and functional reconstitution of monomeric µ-opioid receptors: Allosteric modulation of agonist binding by Gi2. Journal of Biological Chemistry (2009)
30. Pitchiaya S¹ and Krishnan Y^C, First blueprint, now bricks: DNA as construction material on the nanoscale. Chemical Society Reviews (2006)