Our data suggest that the multimeric proteome rapidly responds to changes in hydration and molecular crowding, revealing an unexpected mode of globally programmed phase separation and sequestration that adapts the cell to volume change.

Below are the highlights from the article:

• DCP1A undergoes rapid and reversible hyperosmotic phase separation (HOPS)
• HOPS of DCP1A depends on its trimerization domain
• Self-interacting multivalent proteins (valency ≥ 2) undergo HOPS
• HOPS of CPSF6 may explain transcription termination defects during osmotic stress

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