Our data suggest that the multimeric proteome rapidly responds to changes in hydration and molecular crowding, revealing an unexpected mode of globally programmed phase separation and sequestration that adapts the cell to volume change. Below are the highlights from the article: DCP1A undergoes rapid and reversible hyperosmotic phase separation (HOPS)HOPS of DCP1A depends on its … Continue reading Our new study on hyperosmotic phase separation (HOPS) is on bioRxiv

Dr. Marcin Cieslik (PI) and I (Co-I) have received the Technology Impact Award from Cancer Research Institute to develop a novel method for spatially and clonally resolved profiling of tumor-infiltrating lymphocytes. Thank you CRI for the support- we are excited to kick off this study with potential impact on cancer immunotherapy!

Below are a few highlights from the article: RNAs exhibit diverse spatiotemporal localization patterns at PB core and peripheryExtent of stable or transient RNA-PB interactions depends on RNA functionalityPositioning of cis-regulatory miRNA target sites influences PB interaction kineticsPBs contribute to miRNA surveillance but less to mRNA decay Click here to read the full article. The article … Continue reading Check out our recent article that reveals interesting findings on dynamic recruitment of cellular RNA to P-Bodies

Its official! I have been awarded the Idea Development Award from the Department of Defense (Prostate Cancer Research Program) - my first federal grant as a Principal Investigator - to study tumor composition and heterogeneity. Thank you DoD for the support and for enabling this scientific endeavor that will have an impact on tumor biology … Continue reading Excited to receive my first federal grant from DoD!

Sethu was invited by the Department of Molecular Reproduction, Development and Genetics at IISc to talk about his work on Spatio-temporal resolution of gene regulatory pathways in development and cancer.